the prevalence of thyroid dysfunction in patients with systemic lupus erythematosus
نویسندگان
چکیده
conclusions thyroid dysfunction was not higher in sle patients compared to healthy individuals. however, anti-tg antibodies were higher in sle patients. it has not yet been established that thyroid function tests should be performed routinely in sle patients. results the mean age of sle patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (p = 0.821). patients had significantly higher prevalence (43.2% vs. 23.9%; p = 0.015) and titers (221.8 ± 570.5 vs. 78.2 ± 277.2; p = 0.036) of antibodies to tg compared to controls. the patients had significantly lower titers of t3 compared to controls (125.2 ± 35.6 vs. 136.2 ± 26.5; p = 0.021). the titers of t4, tsh and anti-tpo antibody did not differ significantly between the two study groups. objectives the aim of this study was to evaluate the prevalence of thyroid dysfunction and thyroid auto-antibodies in patients with sle and its relation to sle disease and other autoantibodies. patients and methods this was a case-control study. the study included a total of 88 patients with sle and 88 age- and sex-matched healthy volunteers as control group. two study groups were compared regarding thyroid function test, antinuclear antibody (ana), antibodies to double-stranded dna (dsdna), anti- thyroglobulin antibody (anti-tg), and anti-thyroid peroxidase (anti-tpo) antibody. background systemic lupus erythematosus (sle) is a multisystemic autoimmune disease caused by immune system-mediated tissue damage. autoimmune thyroiditis (at) is an organ-specific disease associated with production of a variety of antibodies such as antinuclear antibodies, anti-double-stranded dna, anti-ro antibodies and anti-cardiolipin antibodies.
منابع مشابه
Prevalence of thyroid dysfunction in systemic lupus erythematosus.
OBJECTIVE To report the prevalence and clinical relevance of autoimmune thyroid disease and thyroid antibodies in 524 patients with SLE. METHODS The medical charts of SLE patients followed in our rheumatology unit were reviewed to determine the prevalence and clinical associations of autoimmune thyroid disease. These findings were compared with the prevalence of autoimmune thyroid disease in ...
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عنوان ژورنال:
iranian red crescent medical journalجلد ۱۷، شماره ۱۲، صفحات ۰-۰
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